If you're having trouble finding a domain name (whether because of crowding or cyber-squatters), check for a help facility on each registrar's site. Domain registrars typically house search engines that return a listing of available names similar to the one you want. When you search for a domain name at Namecheap, for example, you get both the status of that name and a list of suffixes available for that name. Maybe [Sitename].com isn't available, but [Sitename].biz or .org is.
The right to use a domain name is delegated by domain name registrars, which are accredited by the Internet Corporation for Assigned Names and Numbers (ICANN), the organization charged with overseeing the name and number systems of the Internet. In addition to ICANN, each top-level domain (TLD) is maintained and serviced technically by an administrative organization operating a registry. A registry is responsible for maintaining the database of names registered within the TLD it administers. The registry receives registration information from each domain name registrar authorized to assign names in the corresponding TLD and publishes the information using a special service, the WHOIS protocol.
Domain names are organized in subordinate levels (subdomains) of the DNS root domain, which is nameless. The first-level set of domain names are the top-level domains (TLDs), including the generic top-level domains (gTLDs), such as the prominent domains com, info, net, edu, and org, and the country code top-level domains (ccTLDs). Below these top-level domains in the DNS hierarchy are the second-level and third-level domain names that are typically open for reservation by end-users who wish to connect local area networks to the Internet, create other publicly accessible Internet resources or run web sites.
Domain name registrars, in case you didn't know, are the companies that manage all the website domain names you'll see (EG: Inc.com) - the fingerprint of your business, which may also include the hosting and privacy measures. For example, by default many companies will actually over-price the simple process of keeping your registration information private (which if it isn't can be found via a simple Whois search).
If you ever change your web host (the actual physical location of your website files), your domain name goes with you. Your regular visitors or customers who knew your site name as (say) www.thesitewizard.com would not have to be informed about a change of web address (also known as "URL"), since as far as they are concerned, the site is still at the same place. They would simply type your domain name and they'd be transparently brought to your new location.
In order to register any domain, you must provide certain personal information that you may not wish to be publically searchable in the Whois database. Signing up for WhoisGuard is a great way to keep your registration data private. WhoisGuard acts as a "shield" for your searchable information, displaying the address, phone number, and email of the domain registrar (Namecheap, e.g.) instead of your own. Keep in mind that WhoisGuard is an optional security add-on that must be renewed separately when you renew your domain.