Domain names used in works of fiction have often been registered in the DNS, either by their creators or by cybersquatters attempting to profit from it. This phenomenon prompted NBC to purchase the domain name Hornymanatee.com after talk-show host Conan O'Brien spoke the name while ad-libbing on his show. O'Brien subsequently created a website based on the concept and used it as a running gag on the show.
Many online shops have the number 24 in them, to signify 24 hours a day – you may also be able to integrate numbers into your domain in a meaningful way to make them unique. Be careful though, because many cultures attach a lot of significance to certain numbers. Make sure that your number doesn't represent bad luck or other negative things in the country you're operating in.
The hierarchy of domains descends from the right to the left label in the name; each label to the left specifies a subdivision, or subdomain of the domain to the right. For example: the label example specifies a node example.com as a subdomain of the com domain, and www is a label to create www.example.com, a subdomain of example.com. Each label may contain from 1 to 63 octets. The empty label is reserved for the root node and when fully qualified is expressed as the empty label terminated by a dot. The full domain name may not exceed a total length of 253 ASCII characters in its textual representation. Thus, when using a single character per label, the limit is 127 levels: 127 characters plus 126 dots have a total length of 253. In practice, some domain registries may have shorter limits.
Even if the term isn’t trademarked, don’t buy domains that are just a variation of another domain name. This means avoiding plurals if the singular is taken (mediatemple.net vs. mediatemples.net), hyphenating a phrase (media-temple.net), or adding “my” or some other preposition (mymediatemple.net). Alternately, you might consider buying these variations yourself and set them up so that if someone types one of the variations, they are redirected to your main site.
It's good to decide early on if you want to have a brand domain or a keyword domain. The benefit of a brand domain is that your domain will most likely be considered as trustworthy, and immediately shows visitors that it's linked to your business or personal blog. A keyword domain, on the other hand, has the advantage that it will be better optimized for search engines, and therefore will get higher search results. In recent years, however, the drastic improvement in search results thanks to a keyword domain has begun to decrease.
If you're having trouble finding a domain name (whether because of crowding or cyber-squatters), check for a help facility on each registrar's site. Domain registrars typically house search engines that return a listing of available names similar to the one you want. When you search for a domain name at Namecheap, for example, you get both the status of that name and a list of suffixes available for that name. Maybe [Sitename].com isn't available, but [Sitename].biz or .org is.