The longer your domain name is, the harder it is for people to remember it and the more chance you have of someone misspelling one of the words. Most good single word domain names are long gone, but you can still avoid long domain names by getting a little creative. If you have a single word you really like that is not available, try adding an adjective or verb in front of it and seeing if those variations are available. Think of your domain name as part of your brand, and make sure it matches how you want people to think of you.
If you're having trouble finding a domain name (whether because of crowding or cyber-squatters), check for a help facility on each registrar's site. Domain registrars typically house search engines that return a listing of available names similar to the one you want. When you search for a domain name at Namecheap, for example, you get both the status of that name and a list of suffixes available for that name. Maybe [Sitename].com isn't available, but [Sitename].biz or .org is.
If you ever change your web host (the actual physical location of your website files), your domain name goes with you. Your regular visitors or customers who knew your site name as (say) www.thesitewizard.com would not have to be informed about a change of web address (also known as "URL"), since as far as they are concerned, the site is still at the same place. They would simply type your domain name and they'd be transparently brought to your new location.
A great domain name is a concise, easy to type, and memorable URL that reflects your brand or your website’s subject matter. Avoid using hyphens, strings of numbers, or unnecessary words to make it easy for your visitors to remember and find your website. Remember: A great domain name is one that your visitors can type correctly on their first try.