For the most part, you can pick whichever TLD you prefer, though a few have restrictions -- you can't buy a .edu domain unless you run an accredited post-secondary school. Many, but not all, country-specific domains (.us, .uk, .jp) are restricted to citizens of the country in question. Unrestricted country domains are often used for "domain hacks," where the extension becomes part of the title, such as YouTube's alternate address, "youtu.be."
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Next are third-level domains, which are written immediately to the left of a second-level domain. There can be fourth- and fifth-level domains, and so on, with virtually no limitation. An example of an operational domain name with four levels of domain labels is sos.state.oh.us. Each label is separated by a full stop (dot). 'sos' is said to be a sub-domain of 'state.oh.us', and 'state' a sub-domain of 'oh.us', etc. In general, subdomains are domains subordinate to their parent domain. An example of very deep levels of subdomain ordering are the IPv6 reverse resolution DNS zones, e.g., 1.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.ip6.arpa, which is the reverse DNS resolution domain name for the IP address of a loopback interface, or the localhost name.
There is also what is called a ccTLD, or country code top-level domain. These are designed to signify sites located in or associated with certain countries or territories. Most of the ccTLDs actually don't have restrictions regarding who can register domain names. In fact, many ccTLDs are commonly misinterpreted as TLDs. For example, while .tv is commonly registered by television and media related websites, .tv is actually the ccTLD designated for the country Tuvalu. Domain hacks are also a popular use of both TLDs and ccTLDs. This involves creating a full word or phrase when combining the domain name with the TLD to create something your audience will easily remember. A popular example is using the .me ccTLD for Montenegro and combining it with "aweso" to create the domain aweso.me.
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In order to register any domain, you must provide certain personal information that you may not wish to be publically searchable in the Whois database. Signing up for WhoisGuard is a great way to keep your registration data private. WhoisGuard acts as a "shield" for your searchable information, displaying the address, phone number, and email of the domain registrar (Namecheap, e.g.) instead of your own. Keep in mind that WhoisGuard is an optional security add-on that must be renewed separately when you renew your domain.
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