For the most part, you can pick whichever TLD you prefer, though a few have restrictions -- you can't buy a .edu domain unless you run an accredited post-secondary school. Many, but not all, country-specific domains (.us, .uk, .jp) are restricted to citizens of the country in question. Unrestricted country domains are often used for "domain hacks," where the extension becomes part of the title, such as YouTube's alternate address, "youtu.be."
Second-level (or lower-level, depending on the established parent hierarchy) domain names are often created based on the name of a company (e.g., bbc.co.uk), product or service (e.g. hotmail.com). Below these levels, the next domain name component has been used to designate a particular host server. Therefore, ftp.example.com might be an FTP server, www.example.com would be a World Wide Web server, and mail.example.com could be an email server, each intended to perform only the implied function. Modern technology allows multiple physical servers with either different (cf. load balancing) or even identical addresses (cf. anycast) to serve a single hostname or domain name, or multiple domain names to be served by a single computer. The latter is very popular in Web hosting service centers, where service providers host the websites of many organizations on just a few servers.
A great domain name is a concise, easy to type, and memorable URL that reflects your brand or your website’s subject matter. Avoid using hyphens, strings of numbers, or unnecessary words to make it easy for your visitors to remember and find your website. Remember: A great domain name is one that your visitors can type correctly on their first try.
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