Even if the term isn’t trademarked, don’t buy domains that are just a variation of another domain name. This means avoiding plurals if the singular is taken (mediatemple.net vs. mediatemples.net), hyphenating a phrase (media-temple.net), or adding “my” or some other preposition (mymediatemple.net). Alternately, you might consider buying these variations yourself and set them up so that if someone types one of the variations, they are redirected to your main site.

Not every registrar sells every top-level domain, so if you want an uncommon TLD like .pizza, you might have to try a few registrars. Unusual TLDs often cost more than a standard .com address, but provide built-in memorability and give you more name options, since far fewer .pizza addresses are already taken. You can check name availability at any registrar that offers the TLD you want.

HostGator is a company I used for many years with an old firm, and I've found them to be fairly reliable as a rock-solid grounding for a bandwidth-heavy site. Their control panel is also fairly powerful, allowing you to automatically control your fleet of names, as well as locking them down so that nobody can snipe them if you accidentally let a renewal lapse. Their prices are competitive but not the best, but I've found them to be immensely reliable in the past.  Read our HostGator Review.

Avoid having numbers in your domain name. People can get confused about whether the numbers is a digit (3) or a word (three). If you want a number in your domain name because there’s a number in your company name, buy both versions (digit and word) and redirect one to the other. Be especially wary about using the number “0” in a domain name as people may see it as the letter “O.”

Registrars offer a wide variety of registration durations—one year, three, five, and even ten. Be careful about registering for more than a year, though. First, there might be restrictions on your ability to transfer the domain name should the registrar give poor service. Second, the registrar could go out of business, leaving your domain name without a host. Check the policies closely.
What’s easy to forget, though, is that Verisign have managed .com for the past 20 years without so much as a hiccup of disruption or downtime, and that there’s no guarantee that a more democratic or competitive process would have resulted in the 2 decades of .com stability that we’ve enjoyed. Internet governance is obviously important, but we should remember that the overwhelming majority of users don’t know or care what’s going on behind the scenes.
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Those trading domains for commercial purposes are generally on the prowl for lucrative domain endings. There are essentially two different ways traders go about making money off of domain names. One method entails purchasing already established names for a low price and selling them for a profit later once their value has increased. Another strategy involves buying and registering a domain that is thought to possess a high sales potential. Many domain traders use backorder services. These services automatically register a domain when one becomes available or is deleted (what are known as expired domains).
There is also what is called a ccTLD, or country code top-level domain. These are designed to signify sites located in or associated with certain countries or territories. Most of the ccTLDs actually don't have restrictions regarding who can register domain names. In fact, many ccTLDs are commonly misinterpreted as TLDs. For example, while .tv is commonly registered by television and media related websites, .tv is actually the ccTLD designated for the country Tuvalu. Domain hacks are also a popular use of both TLDs and ccTLDs. This involves creating a full word or phrase when combining the domain name with the TLD to create something your audience will easily remember. A popular example is using the .me ccTLD for Montenegro and combining it with "aweso" to create the domain aweso.me.
Domain names are organized in subordinate levels (subdomains) of the DNS root domain, which is nameless. The first-level set of domain names are the top-level domains (TLDs), including the generic top-level domains (gTLDs), such as the prominent domains com, info, net, edu, and org, and the country code top-level domains (ccTLDs). Below these top-level domains in the DNS hierarchy are the second-level and third-level domain names that are typically open for reservation by end-users who wish to connect local area networks to the Internet, create other publicly accessible Internet resources or run web sites.