If you're having trouble finding a domain name (whether because of crowding or cyber-squatters), check for a help facility on each registrar's site. Domain registrars typically house search engines that return a listing of available names similar to the one you want. When you search for a domain name at Namecheap, for example, you get both the status of that name and a list of suffixes available for that name. Maybe [Sitename].com isn't available, but [Sitename].biz or .org is.
Many online shops have the number 24 in them, to signify 24 hours a day – you may also be able to integrate numbers into your domain in a meaningful way to make them unique. Be careful though, because many cultures attach a lot of significance to certain numbers. Make sure that your number doesn't represent bad luck or other negative things in the country you're operating in.
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Sedo is where I bought my domain - over Escrow - and is a global marketplace to buy, sell, and park domain names. They've over 18 million domain names for sale, but the big part is that they're a huge, well-respected company. This may not be important if you're spending $150 on a domain, but in a $15,000+ purchase - which happens in many cases - you will be potentially buying from a foreign entity, that you don't know, and many of them will suggest an escrow payment. This means you put the money in an account owned by a third party that will hold it and only pass it on once the domain has been transferred over into their name (which in this case is what Sedo does). This can be quite disconcerting - but Sedo is well-known and has done many, many deals - and the process is about as full of hand-holding as handing tens or hundreds of thousands of dollars for a domain name can be.
Next are third-level domains, which are written immediately to the left of a second-level domain. There can be fourth- and fifth-level domains, and so on, with virtually no limitation. An example of an operational domain name with four levels of domain labels is sos.state.oh.us. Each label is separated by a full stop (dot). 'sos' is said to be a sub-domain of 'state.oh.us', and 'state' a sub-domain of 'oh.us', etc. In general, subdomains are domains subordinate to their parent domain. An example of very deep levels of subdomain ordering are the IPv6 reverse resolution DNS zones, e.g., 126.96.36.199.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.0.ip6.arpa, which is the reverse DNS resolution domain name for the IP address of a loopback interface, or the localhost name.
If you ever change your web host (the actual physical location of your website files), your domain name goes with you. Your regular visitors or customers who knew your site name as (say) www.thesitewizard.com would not have to be informed about a change of web address (also known as "URL"), since as far as they are concerned, the site is still at the same place. They would simply type your domain name and they'd be transparently brought to your new location.
Domain name registrars, in case you didn't know, are the companies that manage all the website domain names you'll see (EG: Inc.com) - the fingerprint of your business, which may also include the hosting and privacy measures. For example, by default many companies will actually over-price the simple process of keeping your registration information private (which if it isn't can be found via a simple Whois search).
A handful of domains will have restrictions on them, which means you can only purchase them if you meet certain criteria or have authorization (some examples are .gov, .edu. and .mil). But most extensions are available to everyone. In fact, most country code Top Level Domains (ccTLDs) are available for anyone to purchase, even if you don’t reside in the country in question.
If you do not have a web host, you can always allow the registrar to park your domain name at a temporary website specially set up for you. This way you can quickly secure your domain name before it's too late and still take your time to set up the other aspects of your site. As far as I can tell, most registrars (or probably all) automatically park your domain by default whether you ask them to or not, so if this is your situation, you probably don't have to do anything special to get it done. Some of those registrars also provide you with a free email address at your own domain name while it is parked at their site, like firstname.lastname@example.org (where "example.com" is your domain).
What’s easy to forget, though, is that Verisign have managed .com for the past 20 years without so much as a hiccup of disruption or downtime, and that there’s no guarantee that a more democratic or competitive process would have resulted in the 2 decades of .com stability that we’ve enjoyed. Internet governance is obviously important, but we should remember that the overwhelming majority of users don’t know or care what’s going on behind the scenes.
In order to register any domain, you must provide certain personal information that you may not wish to be publically searchable in the Whois database. Signing up for WhoisGuard is a great way to keep your registration data private. WhoisGuard acts as a "shield" for your searchable information, displaying the address, phone number, and email of the domain registrar (Namecheap, e.g.) instead of your own. Keep in mind that WhoisGuard is an optional security add-on that must be renewed separately when you renew your domain.