Avoid having numbers in your domain name. People can get confused about whether the numbers is a digit (3) or a word (three). If you want a number in your domain name because there’s a number in your company name, buy both versions (digit and word) and redirect one to the other. Be especially wary about using the number “0” in a domain name as people may see it as the letter “O.”
Domain name registrations are priced on a subscription-like model that allows a person or business to register that domain name for a certain period of time (usually in annual increments). At the end of the registration period, you (the domain name registrant) have the option to renew the domain name registration for an additional period of time, or let it expire. It is important to renew your domain name registration, or you may find that all of your work building traffic and views to your site ends up benefiting someone else (in the instance that someone else registers your domain name after you let your registration expire), and potentially costing you more in rebranding.
If you're having trouble finding a domain name (whether because of crowding or cyber-squatters), check for a help facility on each registrar's site. Domain registrars typically house search engines that return a listing of available names similar to the one you want. When you search for a domain name at Namecheap, for example, you get both the status of that name and a list of suffixes available for that name. Maybe [Sitename].com isn't available, but [Sitename].biz or .org is.
Who is in charge of all of these processes? Most countries manage a Network Information Center (NIC). An NIC is the main database that has all the information regarding what domain names have been registered and the IP address associated with each of those domains. The nonprofit organization the Internet Corporation for Assigned Names and Numbers (ICANN) is in charge of creating and managing the procedures for internet namespaces.